Original Model Status

Model curated, but did not run in PCEnv simulator. Documentation was also incomplete and not comprehensive.

Work done on model:

Initially, under the 'Mechanical Constitutive Laws' section of the CellML repository, the Guccione 1991 citation had 5 subversions. After clarification from Martyn Nash, it was found that version 2 corresponded to the 'orthotropic exponential constitutive relationship' in the publication titled 'Modelling Cardiac Mechanical properties in three dimensions'.

I rewrote the documentation for models 1,2,4 and 5 under the old Guccione citation, and also put them under their own citations corresponding to which publication they drew ideas or concepts from.

This model had previously been curated under a different citation, and PCEnv had been unable to simulate any results from the corresponding publication. Upon loading the model, PCEnv gave errors regarding the model being 'unsuitably constrained'. This particular model was tagged under the 'Mechanical Constitutive Laws' section in the CellML repository; since it was tagged in this section it was decided to check if the file worked in CMISS. Upon clarifying with James, it was decided that we should ask around the institute and see if the file was being utilized in CMISS and by any one else. Feedback from people in the institute suggested that the file was compliant within CMISS and that it was being used.

Also, the documentation for this model was incomplete and not comprehensive, and so I redid the documentation. Originally the documentation stipulated that this model was the Guccione Orthotropic Exponential law, but upon reading the Publication by Costa et. al., it was clear that this was not the Guccione law, but a 3D treatment of a variation of one of the many Guccione material laws (Mechanical Constitutive Laws).

Curation Status:

Model still does not run in PCEnv simulator, as it (PCEnv) cannot handle matrices and these mechanical laws involve the use of many transformation matrices. It does however run in CMISS and is functioning correctly. Documentation is also clear and concise and people seeking the particular Costa law now have a more indepth and accurate synopsis in both the documentation and model page, so they know this is exactly what they are after.

Further work required:

Curate the model to an extent where it may one day run in PCEnv, this is dependant on when PCEnv will be able to integrate matrix functionality. Perhaps include some diagrams in the documentation as the documentation (although written to not be too technical) may still be confusing for people who are unfamiliar with this topic or field of study.