bhalla_1999

Original Status:

This model is in fact comprised of a network of about 15 pathway models. Catherine has coded up each pathway model, but none are parameterised.

Work done on model:

The Iyengar laboratory website provides all the reaction diagrams and simulation parameters for all of the pathways. I have derived differential equations describing all the reactions for all pathways. The model is a compartmental model, however, and incorporates other models of AMPA receptors and the pathways are imbedded in a model of a hippocampal neuron. All species concentrations need to be converted to allow for compartmentalisation. The pathways then all need to be connected up using 1.1. This is complex and confusing. Mike Cooling has got a working simulation of the model running in its native Genesis using the Kinetikit extension, which he is going to show me.

Curation status:

None of the separate pathway models work

Further work required:

Create all the pathway models using the equations I have derived, allowing for compartmentalization. Stitch up the network and embed it in the hippocampal neuron model with the AMPA receptor model. I don't think this is going to happen in a hurry.

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